SS-31

SS-31 – Mitochondria-Targeted Peptide for Cellular Energy and Oxidative Stress Research

Overview:
SS-31 (also known as Elamipretide) is a synthetic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂) studied for its ability to target and stabilize mitochondrial membranes while reducing oxidative stress. It has become a focal compound in mitochondrial and aging research for its role in enhancing ATP production, minimizing reactive oxygen species (ROS), and supporting cellular energy efficiency in preclinical models.

Scientific Background:
Unlike most antioxidants that act indirectly, SS-31 selectively binds to cardiolipin, a phospholipid found exclusively in the inner mitochondrial membrane. This interaction helps preserve mitochondrial structure and function, protecting against oxidative damage and improving electron transport chain performance. In controlled research settings, SS-31 has been shown to improve bioenergetic output, reduce apoptosis, and enhance mitochondrial resilience in tissues under stress.

Why Researchers Study SS-31:
SS-31 provides a powerful model for exploring the relationship between mitochondrial function, oxidative stress, and cellular aging. Its ability to act directly on cardiolipin and improve mitochondrial coupling efficiency makes it a leading compound in studies of cellular performance, fatigue, and metabolic health.

For Laboratory Research Use Only. Not for Human Consumption.